The Plague Isn’t a Problem.
For Now.
HELP KEEP IT THAT WAY.

Believe it or not, there is no approved plague vaccine. Research studies are enrolling healthy 18- to 55-year-olds for vaccine testing to keep the plague at bay.

Research studies are enrolling today!

Research studies are enrolling healthy 18-55-year-olds for investigational vaccine testing.

Qualified volunteers may receive:

No-cost study-related care
from local doctors and specialists

Study medication
at no cost

The satisfaction of supporting
the men and women of the
armed services

Research studies are enrolling today!

Protection against the plague and outbreak prevention. There is no FDA-approved plague vaccine, and history has shown that plague can be disfiguring and fatal. This study is designed to test a possible plague vaccine specifically designed to fight the pneumatic form of the disease.
No, absolutely not. The injection we are testing doesn’t contain the plague bacteria and therefore cannot cause plague.
This experimental vaccine starts with an adenovirus (the same virus that causes a cold) that has been weakened so it cannot infect people. Then it is genetically altered so it reacts to plague bacterium to make proteins, which, in turn, teach the immune system to fight off the plague infection should it ever need to. What’s being tested is combining this vaccine with an “adjuvant,” which is an immunological substance that combines with a specific protein (antigen) to supercharge that immune response and provide better protection than with an antigen alone.
Sure, the adjuvant being used is called CpG 1018. In pre-clinical and clinical studies of other vaccine studies (Hepatitis B, COVID-19), it has shown to help increase antibody concentrations and stimulate immune system memory responses.
No, we will never expose you to the plague in any way. We will use clinical methods to measure your body’s immune response.
While rare, the plague poses several threats. While not likely, there is a danger of an outbreak or pandemic that could stress the healthcare system, especially in developing countries. Also, there are some occupations and activities that could put certain populations at greater risk. Veterinarians, military personnel, livestock handlers, hunters, and outdoor enthusiasts in areas where the plague is active all run this risk. We believe in being prepared.

How does study matching work?

Answer some questions
about your health

Tell us a little bit about yourself

Connect to available studies
in your area

The Plague is Real

The plague is a particularly nasty disease caused by a zoonotic bacterium called Y. pestis. You’ve probably heard it called the Black Plague or the Black Death but that refers only to the Bubonic form, which caused millions of deaths in Europe starting in 1347.

In total there are three versions: Bubonic, Septicemic, and Pneumonic. The severity of the disease is unquestioned. While survivable with today’s medicine, one of the hallmarks of plague is the development of gangrene in the extremities, which can leave people scarred and disabled for life. Also, plague may be more prevalent in developing countries without access to first world medicines, so a vaccine could go a long way to improving survivability in these areas. But it’s the Pneumonic form that’s especially frightening. It is almost always fatal. If this highly virulent and deadly version of the Y. pestis bacterium is breathed in, by the time symptoms are recognized, it is usually too late to treat.

The Plague is Rare

In the United States, a common belief is that the plague is a foreign disease or that it has been eradicated. Neither is the case. There has been at least one reported case of the plague in the U.S. every year since 2000. The highest number was 17, reached in 2006. Tragically, four people died from the plague in 2015.

The plague does not discriminate by any measure. It infects people of any age from infants to the elderly; male, female, non-binary; and every race and socioeconomic class. Most cases occur in those 12-45 years old. The most at-risk include veterinary professionals, outdoor enthusiasts, and hunters. If there is good news, it’s that it currently only affects half the country. Except for an isolated, lab-associated case in Illinois, cases in the U.S. are clustered in western regions, particularly the rural southwest.

The Plague is Now

So how does the plague spread? Typically, it’s the mighty flea to blame. Vermin like chipmunks, mice and squirrels are common carriers of the plague. When a flea feeds on an infected host, it becomes a carrier and can interact with people directly or through a pet like a cat or dog.

Another way to contract plague is by handling the infected skins, flesh or fluids of infected animals. Obviously, veterinarians and hunters should be especially careful when handling animals.

Breathing in infected droplets is the least common form of transmission. This occurs when someone who has plague pneumonia coughs droplets into the air that are subsequently breathed in by another person. Infected cats also transmit the disease this way.

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When a flea feeds on an infected host, it becomes a carrier and can interact with people directly or through a pet like a cat or dog.

How Does Study Matching Work?

We’d like to learn more about you in order to find a study that’s a good fit. Studies may have different age or health requirements.
Based on the information you give us, we’ll try to match you to a suitable study in your area. If we can’t find a good match for you, we’ll keep you in mind for future studies and notify you when they become available
The study team will ask questions and check your health to make sure that the study is right for you. This visit can be conducted in person at the study clinic or by an online video call from the comfort of your home
If you join a study, you may be asked to make visits to the study clinic or have online video visits. You may receive an investigational (experimental) vaccine or drug as part of your participation.

Remember,

Telehealth visits are available.

Odds are you’ll never get the plague, but it’s still around in high-risk areas.

That’s why we’re trying to keep the plague at bay.

See if you qualify for this investigational vaccine clinical research study.

Another way to contract plague is by handling the infected skins, flesh or fluids of infected animals.

Obviously, veterinarians and hunters should be especially careful when handling animals.

About Clincal Research

Clinical research studies are research projects done with human volunteers to find out if new vaccines and medications are safe and effective. In clinical research studies, the participants get an investigational vaccine or treatment under the care of a doctor and other medical professionals. The word “investigational” means it isn’t available or approved yet for the regular public.
All clinical research studies are regulated by government agencies. What’s more, they’re reviewed and watched over by panels of qualified doctors, scientists, religious representatives, and other members of the community. These review boards make sure your safety, rights, and welfare are protected, and that the study is being done for ethical and honest reasons. No vaccine or treatment can be completely safe for every person, but research studies help make sure the benefits outweigh the possible risks for most people.
Yes! The study team can’t tell anyone that you’re participating in a research study without your permission. The information collected during research studies is kept confidential, and patient names aren’t listed in any reports based on studies.
Clinical research studies need patients with a healthy mix of racial and ethnic backgrounds because drugs and vaccines can affect different groups differently. It’s very important to understand this before new vaccines and treatments can be approved for everyone to use. Also, some groups may be affected by certain diseases more than others. So it’s important to strive for a diverse group of patients in research studies, as long as they meet the requirements for the studies.
If you get matched to a study and have questions for the study team about safety or other concerns, please ask them! It’s actually very important that all your questions are answered and that you feel comfortable about your participation. Also, keep in mind that you may leave research studies at any time, for any reason. The power is yours!

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Research studies are enrolling today!